Interaction study of three overlapping synthetic peptides belonging to E2 protein of GBV-C/HGV with liposomes as biomembrane models

N. Rojo; M. Muñoz; M. Pujol; M.A. Alsina; I. Haro

doi:doi:10.1051/jp4:2004122032

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Numéro		J. Phys. IV France Volume 122, December 2004


Page(s)		211 - 215
DOI		https://doi.org/10.1051/jp4:2004122032

J. Phys. IV France 122 (2004) 211-215
DOI: 10.1051/jp4:2004122032

Interaction study of three overlapping synthetic peptides belonging to E2 protein of GBV-C/HGV with liposomes as biomembrane models

N. Rojo¹, M. Muñoz², M. Pujol², M.A. Alsina² and I. Haro¹

¹ Department of Peptide & Protein Chemistry. Institute for Chemical and Environmental Research (IIQAB-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain
² Unidad Asociada CSIC: "Péptidos y Proteínas: Estudios fisicoquímicos", Department of Physicochemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain

Abstract
In this work we studied by DSC the interaction of three antigenic overlapping peptides belonging to the E2 envelope protein of Hepatitis G virus, namely E2(39-53), E2(32-53) and E2(26-53), with liposomes of different lipid composition (DPPC, DMPC and DMPG) as biomembrane models. The effect of the three selected peptides on the thermotropic behaviour of lipid bilayers has been evaluated.