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J. Phys. IV France
Volume 122, December 2004
Page(s) 211 - 215

J. Phys. IV France 122 (2004) 211-215

DOI: 10.1051/jp4:2004122032

Interaction study of three overlapping synthetic peptides belonging to E2 protein of GBV-C/HGV with liposomes as biomembrane models

N. Rojo1, M. Muñoz2, M. Pujol2, M.A. Alsina2 and I. Haro1

1  Department of Peptide & Protein Chemistry. Institute for Chemical and Environmental Research (IIQAB-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain
2  Unidad Asociada CSIC: "Péptidos y Proteínas: Estudios fisicoquímicos", Department of Physicochemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain

In this work we studied by DSC the interaction of three antigenic overlapping peptides belonging to the E2 envelope protein of Hepatitis G virus, namely E2(39-53), E2(32-53) and E2(26-53), with liposomes of different lipid composition (DPPC, DMPC and DMPG) as biomembrane models. The effect of the three selected peptides on the thermotropic behaviour of lipid bilayers has been evaluated.

© EDP Sciences 2004