J. Phys. IV France 113 (2004) 39
DOI: 10.1051/jp4:20040009
Physicochemical studies of E1(53-66) synthetic peptide by phospholipid monolayers and differential scanning calorimetry
S. Perez1, C. Mestres2, M. Pujol2, M.A. Alsina2 and I. Haro11 Department of Peptide & Protein Chemistry, Institute for Chemical and Environmental Research (IIQAB-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain
2 Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain
Abstract
In the present work, the physicochemical characterization of a hepatitis G virus (HGV)
synthetic peptide by means of two different techniques was studied: lipid monolayers and differential scanning calorimetry
(DSC). We have studied the surface activity of E1(53-66), and its palmitoylated derivative, PalmE1(53-66), and the interactions
of the last one mith dipalmiltoyl phosphatidylcholine (DPPC), and dipalmitoyl phosphatidylglycerol (DPPG) monolayers. Moreover,
DSC was uscd to study the interaction of PalmE1(53-66) with multilamellar liposomes composed of DPPC.
© EDP Sciences 2004