Perturbations induced by synthetic peptides belonging to the E2 structural protein of hepatitis G virus (GBV-C/HGV) in lipid membranes: A differential scanning calorimetry study

C. Larios; J. Carilla; M.A. Busquets; M.A. Alsina; I. Haro

doi:doi:10.1051/jp4:20040007

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Numéro		J. Phys. IV France Volume 113, January 2004


Page(s)		31 - 34
DOI		https://doi.org/10.1051/jp4:20040007

J. Phys. IV France 113 (2004) 31
DOI: 10.1051/jp4:20040007

Perturbations induced by synthetic peptides belonging to the E2 structural protein of hepatitis G virus (GBV-C/HGV) in lipid membranes: A differential scanning calorimetry study

C. Larios^{1, 2}, J. Carilla¹, M.A. Busquets², M.A. Alsina² and I. Haro¹

¹ Institute for Chemical and Environmental Research (IIQAB-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain
² Department of Physical Chemistry, Faculty of Pharmacy (UB), Avda. Joan XXIII, s/n, 08028 Barcelona, Spain

Abstract
In the present work we report the perturbations induced on multilamellar liposomes (MLVs) of different phospholipid composition (DPPC, DMPC, DMPC/DMPG) by peptides that belong to hepatitis G virus (GBV-CHGV). A differential scanning calorimetty (DSC) study was performed with MLVs in the presence of increasing amounts of the three synthetic overlapping peptides from GBV-C/HGV, namely E2(17-26), E2(12-26) and E2(7-26) sequences.