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J. Phys. IV France
Volume 113, January 2004
Page(s) 47 - 49

J. Phys. IV France
113 (2004) 47
DOI: 10.1051/jp4:20040011

Monolayer studies of GHK hydrophobic derivatives

F. Reig1, P. Sospedra2, N. Almiñana1 and A. Ortiz2

1  Department of Peptide and Protein Chemistry, Institute for Chemical and Environmental Research, CSlC, Jordi Girona 18, 08034 Barcelona, Spain
2  Department of Physicochemistry, Faculty of Pharmacy, University of Barcelona, Pza. Pius XII, s/n, 08028 Barcelona, Spain

A peptide sequence involved in collagenase activity has been synthesized as well as its hydrophobic derivatives. The physicochemical properties of the three corresponding peptide analogues are described. Results indicate that decanoyl derivative is the most active as surface activity and monomolecular layer formation are concerned.

© EDP Sciences 2004