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J. Phys. IV France
Volume 11, Numéro PR10, Décembre 2001
Journées d'Étude des Équilibres entre Phases
Page(s) Pr10-247 - Pr10-251
Journées d'Étude des Équilibres entre Phases

J. Phys. IV France 11 (2001) Pr10-247-Pr10-251

DOI: 10.1051/jp4:20011040

Study of the miscibility of the hepatitis A synthetic antigen [L ys]113VP3110 with lipids

P. Sospedra1, M.A. Alsina1, M. Espina1, I. Haro2 and C. Mestres1

1  Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain
2  Department of Peptide & Protein Chemistry, IIQAB-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain

The miscibility of the synthetic peptide antigen of hepatitis A, [Lys]113VP3110 with zwitterionic, anionic and cationic lipids was studied through compression isotherms of monolayers at the air/water interface. Deviations from ideality was found, with a different behaviour to the one observed with the parent peptide VP3(110-121). Deviations were quantified through the calculation of thermodynamic parameters such as the free energy of mixing ΔGEXM), interaction parameter (α) and the enthalpy (ΔH).

© EDP Sciences 2001