J. Phys. IV France 11 (2001) Pr10-247-Pr10-251
Study of the miscibility of the hepatitis A synthetic antigen [L ys]113VP3110 with lipidsP. Sospedra1, M.A. Alsina1, M. Espina1, I. Haro2 and C. Mestres1
1 Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain
2 Department of Peptide & Protein Chemistry, IIQAB-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain
The miscibility of the synthetic peptide antigen of hepatitis A, [Lys]113VP3110 with zwitterionic, anionic and cationic lipids was studied through compression isotherms of monolayers at the air/water interface. Deviations from ideality was found, with a different behaviour to the one observed with the parent peptide VP3(110-121). Deviations were quantified through the calculation of thermodynamic parameters such as the free energy of mixing ΔGEXM), interaction parameter (α) and the enthalpy (ΔH).
© EDP Sciences 2001