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J. Phys. IV France
Volume 11, Numéro PR10, Décembre 2001
Journées d'Étude des Équilibres entre Phases
Page(s) Pr10-227 - Pr10-232
Journées d'Étude des Équilibres entre Phases

J. Phys. IV France 11 (2001) Pr10-227-Pr10-232

DOI: 10.1051/jp4:20011036

Interaction of polymyxin B and A deacilated derivative with monolayers of bacterial lipids

A. Clausell, M. Pujol, M.A. Alsina and Y. Cajal

Department of Physical Chemistry, School of Pharmacy, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain

Polymyxin B (PxB) is a polycationic peptide antibiotic produced by gram-positive bacteria Bacillus polymyxia, and is highly selective against gram-negative organisms. In the present work we have studied the interaction of PxB and PxB-nonapeptide (NP), with lipid monolayers of a lipidic extract from Escherichia coli, a bacteria susceptible to PxB. Kinetics of insertion of both peptides at different surface pressures are compared. Also, the effect of peptides on the phase behaviour of the monolayers is determined from the compression isotherms.

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