J. Phys. IV France
Volume 122, December 2004
|Page(s)||157 - 162|
J. Phys. IV France 122 (2004) 157-162
Resolution of the ethanolamine salt of (±)mandelic acid by using the AS3PC method: Principle, application and resultsE. Aubin, M.N. Petit and G. Coquerel
UC2M2, UPRES EA 3233, Université de Rouen, 76821 Mont Saint-Aignan, France
The ethanolamine salt of (±)mandelic acid crystallizes as a stable conglomerate. This study aims at determining if the racemic mixture could be efficiently resolved by preferential crystallization in the azeotropic mixture: Ethanol - Water at ca. 20°C. Despite the optimisation of several pertinent parameters, the efficiency of the process and the optical purity of the crude crops have been found to remain low (e.e.fmax 5 - 7 % with 65% e.e. purity (e.e. stands for enantiomeric excess)). In order to determine the origin of this poor entrainment effect precise XRPD measurements (on pure enantiomer and racemic mixture) coupled with DSC analyses have been undertaken: the results clearly show the existence of a partial solid solution whose maximal composition is approximately 36% e.e. at 106°C and probably below 10% e.e. at room temperature. Nevertheless the metastable domains of solid solution and/or the high supersaturation created must be also taken into consideration to explain the poor efficiencies.
© EDP Sciences 2004