J. Phys. IV France
Volume 117, October 2004
Page(s) 13 - 16

J. Phys. IV France 117 (2004) 13-16

DOI: 10.1051/jp4:2004117003

Investigation of ketoconazole diffusion into collodion membranes using step-scan FTIR-PAS technique

J. Bodzenta1, B.D. Hanh2, A. Kazmierczak1, R.H.H. Neubert2 and S. Wartewig3

1  Silesian University of Technology, 44-100 Gliwice, Poland
2  Martin Luther University, 06120 Halle/Salle, Germany
3  Institute of Applied Dermatopharmacy, 06120 Halle/Salle, Germany

Results obtained from step-scan Fourier transform infrared photoacoustic spectroscopic (FTIR-PAS) experiments on ketoconazole diffusion into artificial dodecanol-collodion (DDC) membrane are presented. Measurements were performed for two frequencies of 13 Hz and 54 Hz at the spectral range ( $500\div4500$) cm -1. Both in-phase and quadrature components of photoacoustic signal were registered. Analysis of ketoconazole diffusion was carried out for 1512 cm -1 line, whose intensity showed strong dependence on drug concentration. This analysis based on earlier proposed theoretical model of diffusion in a layered system. Experimental dependencies were fitted with theoretical curves using multiparameter fitting procedure. It allowed determination of the diffusion coefficient of ketoconazole in DDC membrane $D = (2.1\pm0.5)\cdot10^{-9}$ cm 2s -1. Obtained results confirmed usability of step-scan FTIR-PAS techniques in investigations of diffusion processes.

© EDP Sciences 2004