Numéro |
J. Phys. IV France
Volume 107, May 2003
|
|
---|---|---|
Page(s) | 513 - 516 | |
DOI | https://doi.org/10.1051/jp4:20030353 |
J. Phys. IV France 107 (2003) 513
DOI: 10.1051/jp4:20030353
Urinary protein excretion profile: A contribution for subclinical renal damage identification among environmental heavy metals exposure in Southeast Brazil
C.R. Garlipp1, P.V. Bottini1, E.M. de Capitan1, M.C. Pinho1, A.D.N. Panzan1, A.M.A. Sakuma2 and M.B. Paoliello31 State University of Campinas, School of Medicine, Clinical Pathology Department, Faculty of Medical Sciences, Universidade Estadual de Campinas, UNICAMP, P.O. Box 6111, 13083-970 Campinas, Sao Paulo, Brazil
2 Instituto Adolfo Lutz, Sao Paulo, Brazil
3 State University of Londrina, Parana, Brazil
Abstract
In Southeast Brazil. Ribeira Valley region has been a major public health concern due to he environmental
heavy metals contamination indexes of vegetation, rocks and aquifers, caused by locai mining in the past. Human
contamination low levels of heavy rnetals doesn't cause acute intoxication but ni chronic exposure, renal damage
may occur with progressive tubuJointerstitial changes evolvil1g to glomemlar 1esiol1, ln this stndy we invesligated the
relationship between thc profile of utillan, excreted proteins (glomerular or lubular origin) of arsenic and mercury and
blood lead concentration in chiJdren and adults from highly e) qJosed regions of the Ribeira Valley. The subjects were
classieed as GROUP 1 (GI; higher environmental risk n=333) and GROUP 2 (G2; lower risk of contamination.
n=104). In order to determine the urinary excretion of total protein, albumin (MA, glomerular marker) and alpha i
microglobulin (AIM, tubular marker) and the blood lead concentrations. random wine and blood samples were
obtaiiied. Plasmatic lead levels were assessed by atomic absorption spectrometty with graphite fumace. Totai protein
concentration (PROT) was assessed on a biochemical analyzer ,progallol red method). MA and AIM were
determined by nephelometric method. Croup 1 showcd a higher frequency of altered urinary excretion of PROT
(GI=3.4%; G2=1.0%), MA (Gl=9.0%; G2=5.1%) and AIM (Gt=7.5%, G2=3.8%), without significant differences
between both groups. Elevated arscnic levels were more prevaient among subjects from Group 1 (2.8.8%) and
demonstrated a significant corrolation with abiiormal iirinarv excretion of ilbumin and alpha-l-micrglobulin (
p=0.019).Leadaand mercury levels showed no difference among the groups and no correlation will MAa and/or M.
Oti-c dala suggests that abnormal itrinary protein excretion is relatively frequent in this population independently of the
plasmatic or urinaryl heavy metal levels. The early detection of possible renal damage become necessary for effective
measures can be taken to prevent clinical nephropathies.
© EDP Sciences 2003