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J. Phys. IV France
Volume 11, Numéro PR10, Décembre 2001
Journées d'Étude des Équilibres entre Phases
Page(s) Pr10-221 - Pr10-226
Journées d'Étude des Équilibres entre Phases

J. Phys. IV France 11 (2001) Pr10-221-Pr10-226

DOI: 10.1051/jp4:20011035

Docetaxel : Solid state characterization by X-ray powder diffraction and thermogravimetry

L. Zaske, M.-A. Perrin and F. Leveiller

AVENTIS PHARMA, Global Pharmaceutical Development, Pharmaceutical Sciences, Material and Drug Delivery Design, CRV1, 13 quai Jules Guesde, BP. 14, 94403 Vitry-sur-Seine cedex, France

Docetaxel, a stoichiometric hydrate containing three water molecules per molecule of drug substance, is thermodynamically stable under ambient conditions of pressure, temperature and relative humidity. Dehydration of this form was subjected to X-ray powder diffraction (XRPD) and thermogravimetric experiments. To obtain a better understanding of the observed structural changes between trihydrate and dehydrated forms, the crystalline structure of docetaxel was refined using high resolution XRPD data coupled with an ab initio direct space method.

© EDP Sciences 2001