Journées d'Étude des Équilibres entre Phases

J. Phys. IV France 11 (2001) Pr10-123-Pr10-126
DOI: 10.1051/jp4:20011017

Tetramorphism of fananserine : p, T diagram and stability hierarchy from crystal structure determinations and thermodynamic studies

J. Giovannini^{1, 2}, L. Ter Minassian³, R. Céolin³, S. Toscani³, M.-A. Perrin¹, D. Louër² and F. Leveiller<sup>1

1</sup>  AVENTIS PHARMA, Global Pharmaceutical Development, Pharmaceutical Sciences, Material and Drug Delivery Design, CRV1, 13 quai Jules Guesde, BP. 14, 94403 Vitry-sur-Seine cedex, France
²  Institut de Chimie, Laboratoire de Chimie du Solide et Inorganique Moléculaire, UMR 6511 du CNRS, Cristallographie des Poudres et Réactivité des Solides, Université de Rennes I, avenue du Général Leclerc, 35042 Rennes cedex, France
³  Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Chimie Physique, Université Paris V, 4 avenue de l'Observatoire, 75270 Paris cedex 06, France

Abstract
The structures of four crystalline phases of fananserine have been solved and their melting properties determined. The p-T diagram for this tetramorphism has been constructed by combining these data. Three out of the four solids are associated with stable p-Tdomains. Two of them have a low-pressure enantiotropic character in narrow p-T domains. The fourth one is intrinsically metastable. The stability ranking agrees with that inferred from solubility measurements at room temperature.

© EDP Sciences 2001