J. Phys. IV France
Volume 125, June 2005
Page(s) 789 - 791

J. Phys. IV France 125 (2005) 789-791

DOI: 10.1051/jp4:2005125182

In vivo evaluation of drug delivery after ultrasound application: A new use for the photoacoustic technique

P.R. Barja1, D. Acosta-Avalos1, P.C.B. Rompe1, F.H. dos Anjos1, F.R. Marciano1 and M.D. da Silva2

1  Instituto de Pesquisa & Desenvolvimento (IP & D), Universidade do Vale do Paraíba (UNIVAP), Av. Shishima Hifumi 2911, São José dos Campos 12244-000, SP, Brazil
2  Instituto Nacional de Pesquisas Espaciais (INPE), São José dos Campos, SP, Brazil

Ultrasound application is a therapeutical resource widely employed in physiotherapy. One of its applications is the phonophoresis, a technique in which the ultrasound radiation is utilized to deliver drugs through the skin to soft tissues. The proposal of our study was to employ the Photoacoustic Technique to evaluate the efficacy of such treatment, analyzing if phonophoresis could enhance drug delivery through skin when compared to the more traditional method of manual massage. The configuration of the system employed was such that it was possible to perform in vivo measurements, which is a pre-requisite for this kind of study. The changes observed in the photoacoustic signal amplitude after each form of drug application were attributed to changes in the thermal effusivity of the system, due to penetration of the drug. The technique was able to detect differences in drug delivery between the specified physiotherapy treatments, indicating that phonophoresis enhances drug absorption by tissue.

© EDP Sciences 2005