J. Phys. IV France 125 (2005) 643-647
Development of a photothermoacoustic frequency swept system: Theory and experimentA. Mandelis1, Y. Fan1, G. Spirou2 and A. Vitkin2
1 Center for Advanced Diffusion Wave Technologies, Department of Mechanical and Industrial Engineering, University of Toronto, M5S 3G8, Canada
2 Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Ave, Toronto, ON, M5G 2M9, Canada
This paper reports the theoretical and experimental development of a new frequency-domain correlation and spectral analysis photothermoacoustic (FD-PTA) imaging technique, which is being developed to detect deep-lying tumor masses in turbid biological tissue. Unlike conventional biomedical photoacoustics which uses time-of-flight acoustic information induced by a pulsed laser to indicate the tumor size and location, in this research, a FD-PTA instrument featuring frequency sweep (chirp), heterodyne modulation and lock-in detection of a continuous-wave laser source within the relative transparency window of human tissue (1064 nm) is constructed. Preliminary experimental results are obtained from phantoms with tissue-like optical properties.
© EDP Sciences 2005