Numéro |
J. Phys. IV France
Volume 107, May 2003
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Page(s) | 1309 - 1312 | |
DOI | https://doi.org/10.1051/jp4:20030541 |
J. Phys. IV France 107 (2003) 1309
DOI: 10.1051/jp4:20030541
Oxidant and antioxidant status of cadmium administered rats
S. Toplan, D. Ozcelik, N. Dariyerli and M.C. AkyolcuIstanbul University Cerrahpasa Medical Faculty, Department of Biophysics, Turkey
Abstract
Cadmium is one of the industrial elements that lead environmental pollution. Biological half-life
of cadmium is relatively longer, so its clearance from tissue is considerably long. In present study, oxidant stress and
antioxidant defense mechanism due to exposure to cadmium in rats wanted to be investigated. For such a purpose
adult female wistar albino rats were divided into two as control and experimental groups. During experimental period
while both group animals were fed by standard fodder, cadmium added (20
g Cd/ml as cadmium sulfate) drinking
water was given to experimental group for four weeks. At the end of four weeks blood samples were drawn from
animals under ether anesthesia. As a Last product of lipid peroxidation malondialdehyde (MDA) level, superoxide
dismutas (SOD) activity which is sign of antioxidant defense enzyme activity and glutathione levels (GSH) were
measured. Increase in lipid peroxidation has been observed by increased MDA levels in experimental group
(p
<0.001). SOD enzyme activity was also found to be significantly lower in experimental group (p
<0.001).
Glutathione level of experimental group found to be decreased according to control group values (p
<0.01). As a result
of present study it may be concluded that cadmium may lead to increase in lipid peroxidation. On the other hand
SOD activity and glutathione levels may also be decreased by effect of cadmium in erythrocytes. So the resultant
would be the disturbed antioxidant mechanism
© EDP Sciences 2003