J. Cirne, R. Dormeval, et al.
J. Phys. IV France 134 (2006) 449-452
A 3D modelling of the protrusion and retraction of a single cell during the motiliy and the rollingN. Mefti1, 2, B. Haussy1 and J.F. Ganghoffer2
1 ESEO, 4 rue Merlet de la Boulaye, BP. 30926, 49009 Angers Cedex, France
2 LEMTA-ENSEM, 2 avenue de la Fôret de Haye, BP. 160, 54054 Vandoeuvre Cedex, France
Published online: 26 July 2006
The rolling is an important kind of cell adhesion, especially in the case of the immune mechanism, due to the leukocyte action, which is strongly influenced by molecular affinity . Our purpose, in this paper, is the presentation of a 3D theorical model which describes the behaviour of the contact interface cell-wall during the rolling and the cell deformation. The first point concerns the modelling of the contact interface, which is assimilated to a circular plate, linked to the wall (e.g vein) by elastic springs. The second point concerns the modelling of the active deformation due to the change of the cytoskeleton structure during the cell motility.
© EDP Sciences 2006