J. Phys. IV France 07 (1997) C4-199-C4-208
Grafting of Chemical Groups onto Polymers by Means of RF Plasma Treatments : a Technology for Biomedical ApplicationsP. Favia, R. d'Agostino and F. Palumbo
Dipartimento di Chimica, Università di Bari, Centro di Studio per la Chimica dei Plasmi, CNR, via Orabona 4, 70126 Bari, Italy
A brief review on plasma-processes used in biomedical applications is gesented, along with results obtained by our group on the plasma-grafting of chemical functionalities onto polymers. RF Glow Discharges in NH3/H2 and O2/H2O/H2 feeds have been utilized for grafting nitrogen- (e. g. -NH2) and oxygen-containing (e. g. -OH, -COOH) functionalities onto polymers in a repmducible, controlled, selective fashion. Efficiency and selectivity of the grafting can, in principle, be tuned by optimizing the treatments with a proper, combined use of Actinometry and derivatization-aided Electron Spectroscopy for Chemical Analysis. Grafted -COOH groups have been used as "anchor sites" for immobilizing heparin and highly-sulphated hyaluronic acid in an active, anti-thrombotic form onto polyethylene.
© EDP Sciences 1997