8 ITMP3 / 8éme conférence internationale de photoacoustique et photothermique
J. Phys. IV France 04 (1994) C7-449-C7-451
Fourier transform infrared photoacoustic spectroscopy to study the penetration of substances through skinM.L. Baesso1, R.D. Snook1 and J.J. Andrew2
1 DIAS, UMIST, M60 1QD, Manchester, U.K.
2 Unilever Research, Port Sunlight Laboratory, L63 3JW, Bebington, U.K.
Step-scan Fourier Transform Inflared (FT-IR) Photoacoustic Spectroscopy (PAS) has been used to study the penetration of substances through abdominal pig skin. The experiments were performed in vitro and dimethylsulfoxide (DMSO) was applied either onto the surface or the bottom of the sample. The results demonstrated that DMSO propagated fast through the skin from the bottom surface. The ease of identification of this substance in this spectral range showed the potential of the technique, suggesting that penetration and distribution of other chemicals through the skin can be investigated by FT-IR PAS.
© EDP Sciences 1994